Approach to alternative to animal experiments

At Mandom, based on the principles of animal welfare and the 3Rs* (especially "Replacement"), since 2005 we have been working to strengthen our internal system to develop replacements for animal experiments using three approaches. We will continue to work in this direction to meet the expectations of society.

Reference

The Japanese Society for Alternatives to Animal Experiments

* 3Rs:
Replacement (Using other methods that do not involve animals)
Reduction (Decrease the amount of use of animals)
Refinement (Lessen the suffering caused to animals)

Mandom International Research Grants on Alternative to Animal Experiments

Mandom has been providing grants for research on alternatives to animal experiments since 2008. See below for more details.

Mandom International Research Grants on Alternative to Animal Experiments. (List of research themes)

16th（2023）

Name	Hyunjin Choi
Affiliation	Graduate School of Engineering, University of Tokyo
Research theme	Development of a novel co-culture model for the evaluation of large particle permeability in the human intestinal epithelium

Name	Kohei Yamada
Affiliation	Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka
Research theme	In silico modeling & simulation to alternate inhalation toxicity tests on newly developed materials

Name	Yuuki Furuyama
Affiliation	Department of Applied Biological Science Research, Faculty of Science and Technology, Tokyo University of Science
Research theme	Construction of a new in vitro culture system for skin microbiome

15th（2022）

Name	Yayoi Kamata
Affiliation	Juntendo University Graduate School of Medicine
Research theme	Development of human three-dimensional culture models for atopic dermatitis with hiPSC-derived sensory neurons:application to the development of new antipruritic drugs

Name	Yujii Nashimoto
Affiliation	Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Research theme	Evaluation of effects of tumor microenvironment on metastasis using a microphysiological system

Name	Yuji Komizu
Affiliation	Department of Applied Life Science, Faculty of Biotechnology and Life Sience, Sojo University
Research theme	Expression of Drug Resistance of Human Pancreatic Cancer Cells by Three-Dimensional Culture

14th（2021）

Name	Akinori Takemura
Affiliation	Graduate School of Pharmaceutical Sciences, Chiba University
Research theme	Development of alternative system for detecting the induction of mitochondrial permeability transition using the activation of human-derived platelet

Name	Sanshiro Hanada
Affiliation	Graduate School of Nanobioscience, Yokohama City University
Research theme	Analysis of a vascular spheroid for the prediction of an inflammatory response

Name	Takeshi Hori
Affiliation	Graduate School of Engineering, Tohoku University
Research theme	Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus

13th（2020）

Name	Tadahaya Mizuno
Affiliation	Pharmaceutical Sciences, The University of Tokyo
Research theme	Expansion of application of decomposition analysis for animal replacement

Name	Katsuko S Furukawa
Affiliation	Graduate School of Engineering, The University of Tokyo
Research theme	Development of alternative animal experiment method for physical stimulation model in osteoarthritis

Name	Kazutoshi Iijima
Affiliation	Faculty of Engineering, Yokohama National University
Research theme	Development of protein sensitization test utilizing differentiated THP-1 cells

12th (2019)

Name	Takayuki Yoshimoto
Affiliation	Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University
Research theme	Development of a novel alternative method to animal experiments for evaluation of allergenic potential by human T cells

Name	Huihui Wang
Affiliation	China Medical University
Research theme	Establishment and application of a cell-based high-throughput screening system for identification of cosmetics ingredient oxidative stressors

11th (2018)

Name	Yasunari Kanda
Affiliation	Division of Pharmacology, National Institute of health Sciences
Research theme	Development of in vitro chemical safety assessment using human iPS cells

Name	Takao Ashikaga
Affiliation	Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences
Research theme	Utility of the h-CLAT on the evaluation of respiratory sensitizer

Name	Kumiko Tatsumi
Affiliation	Department of Surgery, Graduate School of Medicine, Kyoto University
Research theme	Development of hepatotoxicity evaluation model utilizing residual resected liver tissue derived from individual patients

10th (2017)

Name	Shinji Sugiura
Affiliation	Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)
Research theme	Development of pressure driven multi-throughput organs-on-a-chip platform.

Name	Kenji Usui
Affiliation	Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Research theme	Development of easy-to-use skin sensitization test for poorly water-soluble substances using peptidyl beads.

9th (2016)

Name	Yuji Yoshiyama
Affiliation	Kitasato University
Research theme	Effects of hydrogen gas on H9c2 cardiomyocytes from ischemia reperfusion injury.

Name	Kousei Ito
Affiliation	Chiba University
Research theme	Establishment of in vitro cell assay system of drug-induced liver injury risk compounds related to mitochondrial toxicity.

8th (2015)

Name	Kouichi Yoshinari
Affiliation	Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Research theme	Development of the prediction method for repeated dose toxicity of chemical compounds based on the statistical data analysis using in vivo toxicity database and in vitro assays.

Name	Seiichi Ishida
Affiliation	National Institute of Health Sciences, Division of Pharmacology
Research theme	Development of in vitro culture system mimicking human liver functionality by the co-culture of HepaRG, human hepatocyte progenitor cell line, and liverstellate cells.

7th (2014)

Name	Toshihiro Ona
Affiliation	Kyushu University
Research theme	Development of universal method in skin stimulus measurement using epidermal keratinocyte mitochondria as a forefront of sensory system for homeostasis maintenance.

Name	Takashi Yoshikado Yuichi Sugiyama
Affiliation	Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Research theme	Prediction of the risk of drug-induced cholestasis based on the functional evaluation of bile canalicular transporters in vitro.

6th (2013)

Name	Satoru Koyanagi
Affiliation	Graduate School of Pharmaceutical Sciences, Kyushu University
Research theme	Establishment of in vitro circadian clock system for evaluation of cell protecting mechanism against oncogenic transformation.

5th (2012)

Name	Hisamitsu Hayashi
Affiliation	Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme	Search for new candidate drugs for Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2).

Name	Hirokazu Kaji
Affiliation	Graduate School of Engineering, Tohoku University
Research theme	Development of a cell-based model of the retina within a microfluidic device.

4th (2011)

Name	Jeong Ik Lee
Affiliation	Konkuk University
Research theme	Development of biomimetic tissues from commercial cell lines: The promising alternative tools for laboratory animals.

Name	Hideto Ariumi
Affiliation	Kitasato University
Research theme	Acetylcholine inhibits the hypoxia and hydrogen peroxide-induced reduction of connexin43 protein in rat cardiomyocytes.

Name	Naoki Yamamoto
Affiliation	Fujita Health University
Research theme	A study of the eye irritation test using new immortalized human corneal epithelium.

3rd (2010)

Name	Hiroyuki Kusuhara
Affiliation	Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme	Establishment of quantitative prediction of in vivo renal clearance based on in vitro data obtained using human derived materials and overexpression systems.

Name	Masahiro Takagi
Affiliation	Japan Advanced Institute of Science and Technology
Research theme	Development of an Alternative method to Draize Test by Analysis of Biomimetic Membrane Dynamics.

2nd (2009)

Name	Kikuo Komori
Affiliation	Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme	Formation and Functional Evaluation of a Minimum Cell Mass for in vitro Toxicity Tests.

Name	Shigehiro Ohdo
Affiliation	Graduate School of Pharmaceutical Sciences, Kyushu University
Research theme	Establishment of chronopharmacokinetic evaluation system in vitro cultured cells: Molecular basis for rhythmic expression of CYP in serum-shocked HepG2 cells.

Name	Kazuya Maeda
Affiliation	Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research theme	Establishment of the methods for quantitative prediction of the detoxification activity of drugs and the risk of drug-drug interactions in the liver by the use of human liver samples and gene expression systems. - Use of human-derived organ samples as alternatives of animal experiments -

1st (2008)

Name	Kenji Sugibayashi
Affiliation	Josai University
Research theme	Permeation of several compounds through different three-dimensional cultured human skin models.

Name	Tsutomu Kurosawa
Affiliation	Osaka University
Research theme	Establishment of the alternative method of animal experiment, using green fluorescent ES and iPS cells.

Name	Jae Hak Park
Affiliation	Seoul National University
Research theme	International Validation of Bovine Corneal Opacity and Permeability (BCOP) assay and introduction of "MCTT Skin model" as an alternative to skin irritation test.

Name	Lee Jeong Ik
Affiliation	Tokai University
Research theme	Study on the hazardous effects of intra-peritoneal injection of anesthetics on internal organs. -Resolution on the mechanism of the direct hazard of anesthetic injection on cell lines derived from the liver cells and pancreatic islet cells in vitro-

Received Distinguished Service Award at the 30th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments

At the 30th annual meeting of the Japanese Society for Alternatives to Animal Experiments in November 2017, our previous research grant activities were recognized for their major contribution to the Japanese Society for Alternatives to Animal Experiments, and we received the Distinguished Service Award from the society.
Through our research grants, Mandom will continue to widely recommend research in the area of alternatives to animal experiments. At the same time, we will contribute to society through participation in the committee activities of the society, promotion of validation initiatives with research institutions to achieve international standardization of new alternatives to animal experiments, and other efforts to further energize research in the alternatives field.

Reference

PDFNovember 27, 2017, News Release "Mandom Receives Distinguished Service Award at the 30th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments" (Japanese only)（PDF:162KB）

Our Position on Animal Experiments

Mandom is working to develop cosmetics based
on a policy of no animal Experiments.

Mandom develops products with the safety of the consumer as our top priority. Fundamentally, the safety testing of our products is to be done on people (patch tests, stinging tests, etc.) and by using alternatives to animal Experiments. No animal Experiments is to be performed, which includes outsourcing. No animal testing will remain our policy in the future.

* This excludes instances where we are held responsible by society to evidence the safety of a product or where it is required by administrations in particular countries

We are grateful for the valuable opinions expressed by our stakeholders, and will reflect them in product development that is both safe and eco-friendly.